【摘要】 目的　研究太安对大鼠主要器官的毒作用。方法　用PETN以食用植物油为溶剂分为 0 ,2 5 ,8 3,2 5mg/kg剂量组给大鼠灌胃 ,每日 1次 ,每周 6次 ,共 90d。在 45d时处死部分动物 ,其余染毒结束后处死 ,取其肝、肾、心、肺、脾脏、睾丸 ,观察其病理改变。结果　大鼠主要器官病理改变与对照组比较差异无显著性。结论　上述染毒条件下PETN未引起大鼠某些主要器官的病理改变更多还原

【Abstract】 Objective To study the toxic effect of PETN on main organs of SD rats.Methods SD rats were divided into four groups and fed with 0,2 5,8 3 and 25mg/kg PETN which was dissolved in plant oil respectively by gastric canal once a day,6 times a week for 90 days.The rats then were killed at 45th day or 90th day,for taking liver,heart,kidney,lung,spleen and testis and observing their pathological changes.Result The organs of administrated rats had no notable pathological changes.Conclusion The dosages of PETN used in this experiment can‘t lead to any visible pathological change of organs in SD rats.更多还原