【摘要】 帕金森病（Parkinson’s disease, PD）是一种以黑质致密部多巴胺能神经元的特异性、进行性坏死为特征的神经系统退行性疾病。尽管PD的发病原因还不十分清楚,目前的证据表明环境因素和遗传因素是PD可能的主要致病因素。针对这两大因素,神经科学家们发展了很多制造PD动物模型的方法。MPTP（1-甲基-4-氨基-1,2,3,6-四氢吡啶）模型是目前比较经典的模型,而新近兴起的基因工程模型亦具有广阔的应用前景。各种PD动物模型推动着人们对PD认识的深入和治疗手段的发展。恰当的动物模型必将成为最终揭开人类帕金森病奥秘的钥匙。更多还原

【Abstract】 Parkinson’s disease (PD) is a neurodegenerative disorder characterized by a specific loss of the dopaminergic neurons of the substantia nigra pars compacta. Although the etiology of PD remains obscure, current evidence shows that environmental or genetic factors might contribute to the pathogenesis of PD. Aiming at these two possible pathogenetic factors, neuro-scientists have developed a variety of animal models of PD. MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)animal model is the classic model at the present, while the new methods of engineered modeling also exhibit bright perspective. All sorts of animal models of PD have contributed greatly to our attempts to understand the pathogenesis of PD and to develop new therapies, and could be the key to unlock the secrets of PD and make major breakthroughs in the future.更多还原