【摘要】 为进行胸痹证型的规范化、标准化研究 ,将 15 0只大鼠分为两大组 (每组 70只 ,另 10只为正常对照组 )。第 1组以垂体后叶素合高分子右旋糖酐 ,造成胸痹心血瘀阻模型 ,第 2组以垂体后叶素合高脂饮食 ,造成胸痹痰浊壅塞模型。并将造模动物分别分成 7组 (每组 10只 ) ,即模型组、丹参组、左归丸组、右归丸组、冠心苏合香组、生脉饮组和半夏栝蒌组 ,分别予相应药物灌胃 (剂量为临床常用量的 10倍 ) ,连续 1W。结果 :血瘀证丹参组和痰浊证半夏栝蒌组的心电图指标有明显改善 (P <0 0 5 )、±dp/dtmax虽有改善趋势但无统计学意义。心血瘀阻证模型组与正常组和各治疗组之间相比 ,cAMP较高 ,但无统计意义。痰浊壅塞证各组和正常组cGMP之间有差异 (P <0 0 5 ) ,痰浊壅塞证模型组三酰甘油含量高于正常组和各治疗组 (P <0 0 5 )。提示辨证论治疗效好于其他治疗组 ,存在一些指标可以作为辨证的依据更多还原

【Abstract】 To standardize the Chinese medical patterns of chest blockage,150 rats were grouped into three parts:the rats in the first part(n=70)that were modeled into blood stasis pattern by pituitrin and Macromolecule Dextran,the rats in the second part(n=70)that were modeled into phlegm turbidity accumulation pattern by pituitrin and high fat diet,the rats(n=10) in the third part being normal control ones.After modeling,the rats in the first two parts were respectively classified into seven groups:model group,Danshen group,Zuogui group,Yougui group,Guanxin group,Shengmai group and Banxia group,10 rats in each,and treated accordingly for one week.Results:The electrocardiogram improved obviously in Danshen group in the first part and Banxia group in the second part(P<0 05),and the ±dp/dtmax tends to improve,but without statistical significance;in the first part,there were no differences of cAMP between the model group and normal control group as well as other groups( P <0 05);in the second part,there were differences cGMP between any group and normal control group(P<0 05),and the triglyceride is higher in model group than any of other groups as well as normal control group(P<0 05).更多还原