【摘要】 目的　观察红花注射液对高血压病血管内皮的保护作用。方法　 70例原发性高血压病 (2～ 3级 ,极高危 )患者 ,随机分为红花注射液治疗组 (2 4例 ) ,丹参注射液治疗组 (2 3例 ) ,无静脉注射治疗对照组 (2 3例 )。比较三组患者用药 2周前后内皮素 (ET)、血栓素 (TXA2 )、一氧化氮 (NO)、前列环素代谢产物 (6 Keto PGF1α)的变化。结果　红花组患者治疗后血浆ET下降 (12 .97± 0 .17) %、TXA2 下降 (15 .2 1± 0 .0 1) % ,NO上升 (4 6 .6 1± 0 .0 6 ) %、6 Keto PGF1α 上升 (2 3.6 5± 2 .5 0 ) % ,与对照组相比 ,差异具有显著性 (P <0 .0 5 )。结论　红花具有抑制ET素及TXA2 和提高血管内皮NO和前列环素的作用 ,临床保护血管内皮功能疗效显著。更多还原

【Abstract】 Objective To observe the protective effect of carthamus flower (Honghua sodium) on the vascular endothelia in hypertensive disease. Methods 70 hypertensive patients in degree of Ⅱ~Ⅲ, were randomly divided into three groups: group 1 (n=24) received honghua infusion, group 2 (n=23) recieved danshen infusion, and the control group (n=23) received infusion without any of the above drug. The ET、TXA 2、NO、6-Keto-PGF 1 α concentrations were measured and compared before and after two weeks treatment. Results After the treatment, in group 1, ET was significantly decreased (12.97±0.17)%, TXA 2 also significantly decreased (15.21±0.01)%, NO was significantly increased (46.61±0.06)%,also the 6-Keto-PGF 1α (23.65±2.50)% much more than those in the control group (P<0.05). Conclusion Honghua sodium has inhibition effect on ET, TXA 2 but elevats NO, 6-Keto-PGF 1α, clinically its effect on protection of vascular endothelia of hypertensives is significant.更多还原