【摘要】 目的以挤压大鼠颈总动脉造成血管损伤 ,观察猪十二指肠类肝素 (冠心舒 )对血管损伤后再狭窄的防治作用。方法 6 0只大鼠随机分为 5组 ,即病理模型组 ,低、中、高剂量冠心舒组及阿司匹林对照组。术前 1周开始灌服药物 ,每天 1次 ,共 4周。术后 3周 ,在光镜下以显微测微计测量、计算内膜增生程度。结果病理模型组 (不给药 )血管内膜横切面积占有率明显增大 ,管腔面积占有率明显缩小 ;与病理模型组比 ,给冠心舒动物血管内膜横切面积剂量依赖地明显缩小 ,管腔面积占有率明显增大 ,并有抑制平滑肌细胞转型及促内皮修复作用。结论冠心舒有抗大鼠颈总动脉挤压伤后再狭窄作用更多还原

【Abstract】 PurposeTo investigate the effects of heparinoid extracted from porcine duodenum (Guanxinshu, Hep) on vascular intima hyperplasia.MethodsSixty rats were randomly devided into 5 groups and given Hep 20, 60, 120 mg/kg, aspirin(9 mg/kg) or normal saline 10 ml/kg (model control group) orally once a day for four weeks respectively, then the vascular intima hyperplasia model was made by external squeezed injury on the rat carotid artery. Three weeks after the injury, the ratio of intima area and the ratio of cavity area of the injured carotid artery were measured by micrometry method.ResultsThe ratio of intima area increased and the ratio of cavity area decreased remarkably in the model control group. Hep could inhibit this change in a dose dependent way. Hep could also inhibit the vascular smooth muscle cell phenotype modulation(from contractile phenotype to synthetic phenotype) and promote the endothelium regeneration.ConclusionHep could prevent the restenosis formation of the rat carotid artery after external squeezed injury.更多还原