【摘要】 目的 :探讨抗原抗体复合物在突出髓核中的分布及临床意义。方法 :应用免疫酶组织化学染色的方法 ,对 31例腰椎间盘突出症患者的突出髓核中抗原抗体复合物进行检测 ,与 2 0例正常椎间盘作对照并结合临床资料分析其意义。结果 :在突出髓核的标本中可在髓核细胞膜周围观察到显示阳性的棕色沉淀物存在 ,而在正常椎间盘对照组中却未见阳性显示。突出型及脱垂游离型髓核中 6 8.4 2 %显示为强阳性 ,31.5 8%显示为阳性 ,膨隆型髓核中 5 8.33%显示为阳性 ,4 1.6 7%显示为阴性。两组之间 P<0 .0 5 ,有统计差异。结论 :在突出髓核组织普遍存在抗原抗体复合物 ,而健康椎间盘中却不含有此免疫复合物。抗原抗体复合物阳性与强阳性表达与髓核暴露于机体免疫系统的程度相关 ,临床疼痛症状的程度与自身免疫反应的程度相关。髓核突出后引起的自身免疫反应是导致神经根慢性炎症的重要原因。更多还原

【Abstract】 Objective:To assess the distribution of antigen-antibody complexes and its clinical significance in the herniated nucleus pulposus.Methods:The presence and distribution of antigen-antibody complexes were detected in 31 cases of herniated nucleus pulposus by the method of immunohistochemistry.The results were compared with those of control subjects and analyzed in connection with clinical finding.Results:A brown deposit,indication antigen-antibody complexes could be observed in the pericellular capsule in herniated disc tissue but not in control discs.There was clear tendency for a more pronounced staining of the pericellular capsule in noncontained herniated tissues than in cotained herniated tissues.68.42% are strong positive,31.58% positive of noncontained hemiated tissues.On the cotrast,58.33% contained nucleus are positive,41.67% negative.There is statistical difference among them( P <0.05).Conclusion:antigen-antibody complexes seem to be commonly present in herniated disc tissue,but not in healthy discs.The expression degree of the Antigen-antibody complexes is correlation with the exposing degree of the herniated nucleus pulposus in the immune system.Experimental evidence exists that the pain of patients will be more sever during the immunologic reaction of the antigen-antibody complex heavier causing by the hemiated nucleus pulposus.It indicates the immunologic reaction might be of important in the pathophysiologic events leading to nerve root injury in disc herniation.更多还原