【摘要】 为探讨人类白细胞抗原 (HL A) - B5 1与白塞病 (BD)之间的相关性 ,应用微量淋巴细胞毒试验对 2 0例BD患者的 HL A- A和 HL A- B抗原进行了检测。同时以 30例正常人作对照组。结果 ,在 BD患者中 ,HL A- B5 l表型频率明显高于对照组 (6 0 % vsl6 .7% ) ,P<0 .0 0 1(校正 P值 <0 .0 5 ) ,相对危险度为 8.98。没有发现其他 HL A-A和 HL A- B抗原与 BD相关。提示 HL A- B5 1抗原与 BD的易感性相关更多还原

【Abstract】 To investigate the correlation between HLA B51 antigen and Behcet’s disease(BD) HLA A and HLA B typing was performed using peripheral blood lymphocytes by the standard US National lnsititutes of Health(NIH)complement dependent microlymphocyte toxicity assay Patients with BD were required to satisfy the international Study Group(1SG) criteria for diagnosis ofBD The control group consisted of 30 healthy people A highly significant HLA B51 association with BD wasd etermined [60% in patients vs 16 7%in controls,χ 2=10 04,P<0 001,Corrected P(Pc)<0 05,relative rigk(RR)=8 98] No other HLA type was associated This supports HLA B5l immunogenetic predisposition and reveales a strong association of BD with HLA B51更多还原