【摘要】 目的:观察益气清热活血方对环磷酰胺诱发小鼠骨髓多染红细胞(PCEs)微核形成的抑制作用及其机制探讨。方法:微核实验和测定小鼠肝组织中谷胱甘肽-S-转移酶(GST)活性、还原性谷胱甘肽(GSH)含量。结果:益气清热活血方对环磷酰胺(CPA)诱发PCEs微核细胞率有较强抑制作用,并能提高肝脏GST活性,升高GSH含量。结论:益气清热活血方对化学诱变剂引起的染色体断裂有一定保护作用,其作用机制可能与提高肝脏的解毒功能有关。更多还原

【Abstract】 The antimutagenic Yiqiqingre Huoxue formula effect on cyclophosphamide(CPA) induced micronu-clear on PCEs in mice bone marrow and the effect on glutathione-S-transferase(GST) activity .glutathione(GSH) level in liver of mice were investigated. The results showed that the CPA-induced micronucleus rate were inhibited from 18- 06% to 48- 69%. The GST activity and GSH level were increased obviously. The experiment suggests that Yiqiqingre Huoxue formula has the effect of inhibiting mutagenesis and is probably due to improve detoxifying function of the liver.更多还原