【摘要】 目的 :评价左旋氧氟沙星治疗呼吸、泌尿、消化系统急性细菌性感染的安全性及有效性。方法 :选择急性细菌性感染患者 ,分为随机对照试验组及开放试验组。随机对照试验中分试验组 :静脉滴注左氟沙星 4 0 0mg ,每天 1次 ,疗程 7～ 14d ,对照组 :静脉滴注氧氟沙星 4 0 0～ 6 0 0mg ,每天 1次 ,疗程 7～ 14d ;开放试验组只滴注左氟沙星。结果 :随机对照试验 :左氟沙星试验组、氧氟沙星对照组痊愈率分别为 74 .6 % (47 6 3)、6 4.5 % (40 6 2 ) ;有效率分别为 96 .8% (6 1 6 3)、88.7% (5 5 6 2 ) ,两组痊愈率、有效率差异均无统计学意义 (P均 >0 .0 5 ) ;开放试验组 :痊愈率、有效率分别为 72 .5 %、95 .0 %。随机对照试验中左氟沙星细菌清除率、阴转率分别为 94 .6 %、94 .5 % ,氧氟沙星细菌清除率、阴转率分别为 88.89%、90 .9% ,两药间比较差异无统计学意义。左氟沙星、氧氟沙星不良反应率分别为 6 .3%、8.1% ,两组差异无统计学意义。结论 :盐酸左氟沙星治疗呼吸、泌尿、消化系统急性细菌性感染 ,安全、有效。更多还原

【Abstract】 Objective:to evaluate the clinical safety and efficacy of Levofloxacin (LVLX) in the treatment of bacterial infections. Methods: The patients with acute bacterial infection were enrolled in randomly controlled trials and open labeled trial. In randomly controlled trials, 400?mg Levofloxacin was given by intravenous drip once a day for 7 to 14 days in the trial group while 400～600?mg Ofloxacin (OFLX) was given in the same manner and for a same period in the control group. The open labeled group was only given Levofloxacin.Results:The cure rate of Levofloxacin and Ofloxacin was 74.6% and 64.5% respectively. The clinical efficacy rate of Levofloxacin and Ofloxacin was 96.8% and 88.7% respectively and the bacterial clearance rate were 94.6% and 88.89% respectively.The difference had no statistical significance. The cure rate, clinical efficacy rate in the open labeled group were 72.5% and 95.0% respectively. Incidence of adverse effects was 6.3% in LVLX group, and 8.1% in the control group. The difference between two groups was of no statistical significance.Conclusion:Levofloxacin is an effective and safe drug in the treatment of acute bacterial infection.更多还原