【摘要】 目的　观察功能矫形前伸青春期大鼠下颌后 ,翼外肌细胞膜乙酰胆碱受体 ( n- Ach R)最大结合容量 ( Bmax)的变化 ,探讨功能矫形的神经肌肉调控机理。方法　选用 2 0只 5周龄 Sprague- Dawley雄性大白鼠 ,随机分为实验组和对照组各 10只。实验组大鼠戴自制上颌功能矫治器 ,引导下颌前伸。采用放射受体分析法测定两组大鼠翼外肌肌细胞膜上乙酰胆碱受体的最大结合容量。结果　实验组大鼠翼外肌细胞膜上乙酰胆碱受体最大结合容量 ( Bmax=2 85 .5 73 fmol/mg pro)明显 >对照组 ( Bmax=2 14 .662 fmol/ mg Pro) ,其差异具有统计学意义 ( P<0 .0 1)。结论　功能矫形可增加翼外肌细胞膜上乙酰胆碱受体与乙酰胆碱的结合量更多还原

【Abstract】 Objective The purpose of this study was to evaluate the maximum binding(Bmax)changes of acetylcholine receptor(n AchR)on rat lateral pterygoid muscle after the function mandibular advancemetn.Methods 20 five weeks old male Sprague Dawley rats were average divided to experiment and control groups.The mimic functional appliances were used in experiment groups and rats were killed after 2 weeks.Radio ligand binding assay(RBA) was applied to determine the maximun binding(Bmax)of n AchR on lateral pterygoid muscle.Results The Bmax of n AchR on experimental group is 285.573(fmol/mg Pro)and above the Bmax((214.662 fmol/mg Pro)of control( P <0.001).Conclusion The functional orthopedics can increase the Bmax of n AchR on rapid growing rat lateral pterygoid muscle.更多还原