【摘要】 人类的肤色是在遗传和环境因素的共同作用下形成的。最近在人类复杂性状基因定位中 ,统计学和遗传学研究方法的发展 ,使得肤色相关基因有可能利用这些方法来甄别。而且 ,有了PhotovoltColorWalk色度计等便携的新式光谱反射系数测量工具 ,研究者可以方便准确地测量大量人群的皮肤反射系数作为遗传学研究用的人类表型性状。我们用PhotovoltColorWalk测试了 372人的一个汉族群体和 2 74人的一个藏族群体的上臂内侧不受阳光照射的皮肤反射系数 ,以建立反射系数测量的基准数据。我们调查了年龄、性别、居住地纬度、种族等不同因素对皮肤反射系数的影响 ,也调查了皮肤反射系数的正态分布。在这些研究结果的基础上我们设计了皮肤反射系数遗传学研究的策略更多还原

【Abstract】 Genetic and environmental factors are involved in the determination of skin pigmentation in humans. With the recent development of statistics and genetic tools in mapping complex traits in humans, it becomes possible to utilize such methods in identifying genes involved in skin pigmentation. Furthermore, the use of new portable reflectance spectroscopy instruments such as the Photovolt ColorWalk colorimeter allows researchers to measure the skin reflectance from a large number of subjects with ease and accuracy for collecting phenotype data for genetic studies. In this report, we studied the skin reflectance of 372 Han Chinese and 274 Tibetan to establish background reflectance measurements of unexposed skin of the inner upper arm in these two populations using a new portable instrument (Photovolt ColorWalk). We investigated the effect of various factors such as age, gender, latitude, and ethnicity on skin reflectance. The normality of the distribution of skin reflectance was also investigated. Strategies for genetic studies of skin reflectance were suggested based on the results of this study.更多还原