【摘要】 【目的】研究青藤碱对于胶原诱导型关节炎 (CIA)大鼠滑膜及表达IL - 6mRNA的影响。【方法】采用CIA大鼠动物模型 ,HE常规病理切片 ,观察青藤碱对滑膜的炎性浸润、巨噬A型细胞增生、纤维组织增生及原代培养滑膜细胞表达IL - 6mRNA的影响。【结果】青藤碱可明显减轻滑膜的炎性浸润、巨噬A细胞和纤维组织增生 ,减少滑膜细胞IL - 6mRNA的表达。【结论】青藤碱可以通过抑制滑膜细胞恶性增殖及IL - 6基因的表达来阻断滑膜炎的进程更多还原

【Abstract】 To study the effects of sinomenine on synovium and expression of IL 6 mRNA in rats with arthritis induced by collagen Ⅱ.Thirty six Wistar rats were divided into six groups: normal control group (group A), model group (group B), high and low dosage sinomenine groups (group C and group D respectively) and high and low dosage methotrexate groups (group E and group F respectively). HE pathological sections of synovial tissue were prepared to observe the influences of sinomenine on inflammatory infiltration, hyperplasia of type A macrophage (MA), hyperplasia of fibrous tissue (FT) and IL 6 mRNA expression from primary cultured synovial fibroblast in model rats with collagen induced arthritis.Sinomenine could markedly reduce the inflammatory infiltration, hyperplasia of MA and FT and decrease the expression of IL 6 mRNA.[Conclusion]Sinomenine can counteract the progress of synovitis by inhibiting the infiltration of synovial fibroblast and the expression of IL 6 mRNA.更多还原