【摘要】 目的　利用工程菌E .coliDH5αPBV2 2 0 IL6制备重组人白细胞介素 6,并探讨白细胞介素 6对辐射豚鼠的生存期和血小板数的影响。方法　将IL -6工程菌诱导表达、纯化后应用于辐射豚鼠的治疗。结果　纯化的IL -6对辐射豚鼠的生存期和血小板数有明显的提高作用。结论　IL -6对辐射豚鼠具有明显的保护作用。更多还原

【Abstract】 Objective To purify recombinant human interleukine-6 from gene-engineered E.coli and study the effects of IL-6 on survival period and platelet count of irradiated guinea-pigs.Methods Recombinant human IL-6 was expressed in gene-engineered E.coli and purified with reversed phase chromatography.Purified IL-6 was then administered to irradiated guinea-pigs.Results IL-6 could significantly prolong the survival period and increase the platelet count of irradiated guinea-pigs.Conclusion IL-6 showed its effective protection for irradiated guinea-pigs.更多还原