【摘要】 目的 :探讨饮用水低剂量微囊藻毒素对大鼠实验性肝癌形成的促癌作用。方法 :应用二乙基亚硝胺 (DEN)致大鼠肝癌前病变细胞增生灶 (Gamma -谷氨酰转肽酶阳性灶 )发生的短期实验模型研究经饮水摄入低剂量微囊藻毒素的促肝癌作用。结果 :二乙基亚硝胺启动后连续 9周饮用含微囊藻毒素0 5 2 9μg/L的藻培养水 ,大鼠肝Gamma 谷氨酰转肽酶阳性灶数量和面积均出现上升趋势。结论 :长期饮用微囊藻毒素污染的水促肝癌作用不可忽视更多还原

【Abstract】 Objective In order to explore the liver tumor promoted activity of drinking microcystins(MC) polluted water on experimental hepatocaroinogenesis.Methods The model for this experiment was a two-stage medium term animal test.After induced by diethylnitrosamine(DEN) initiator the rats drunk MC polluted water (contained MC 0.529 μg/L)9 weeks consistently.The hepatic putative preneoplastic lesions (γ-GT positive foci ) were observed on liver sections.Results The results showed that drinking MC polluted water can enhance both the numbers and areas of γ-GT positive foci in experiment animal.Conclusions This experiment indicated that MC is a liver tumor promoter and its long term effects on hepatocarcinogenesis shouldn’t be ignored in drinking water polluted by MC.更多还原