【摘要】 目的 :探讨膀胱肿瘤患者血清透明质酸 (HyaluronicAcid ,HA)与层粘连蛋白 (Laminin ,LN)的变化及其临床意义。方法 :采用放射免疫分析法分别测定 34例膀胱肿瘤及 30例对照组血清术前与术后HA、LN含量。结果 :膀胱肿瘤组术前血清HA、LN含量均显著高于对照组 (P <0 .0 1) ,术后明显下降 ,手术前后血清HA、LN含量差异有显著性意义 (P <0 .0 5 ) ;浸润性膀胱肿瘤组 (T2 、T3 、T4)与淋巴结转移组血清HA、LN含量均明显高于表浅性膀胱肿瘤组 (Tis、Ta、T1 ) (P <0 .0 5 )与无淋巴结转移组 (P <0 .0 1)。结论 :HA与LN参与膀胱肿瘤的恶性生物学行为 ,可能成为重要的辅助诊断及病情监测指标。更多还原

【Abstract】 Objective: To investigate the Serum levels of Hyaluronic Acid (HA) and laminin (LN) level of serum and its clinical significance in patients with bladder tumors.Methods: the serum samples from 34 patients with bladder tumor and 30 cases as control group were analyzed by radioimmunoassay. Results: the results showed that the HA and LN levels of serum in patients with bladder tumors were significantly higher than those in control group(P<0.01)before operation, and decreased significantly after operation. The serum levels of HA and LN in infiltration tumors were higher than those in superficial tumors(P<0.05).The two markers in patients with lymph node metastasis were higher than that without lymph node metastasis(P<0.01).Conclusion: HA and LN take part in the malignant biology behavior of bladder tumors. They may be the important markers for assistant diagnosis and condition monitoring.更多还原