【摘要】 首先以壳聚糖、海藻酸钠为原料制得含头孢氨苄的微囊 ,再用 κ-卡拉胶对微囊进行多次包埋 ,制成缓释体系 .测定了其在不同 p H值的水溶液中的释药速率 ,并对包埋次数对释药速率的影响和缓解机理进行了初步讨论 .结果表明 ,该缓释体系的释药时间可达 7h,增加包埋次数可延长释药时间更多还原

【Abstract】 A novel sustained release system was obtained by enwrapping chitosan-sodium alginate microcapsules of cefalexinum several times with κ-carrageenan. The rate of drug release in aqueous solutions with different pH values was determined and mechanisms related were discussed. Experimental results showed that increasing enwrapping times could retard drug release and it was possible to sustain the release for a 7 h period.更多还原