【摘要】 目的 :研究尼莫地平分子微囊剂在狗体内的药动学行为 ,为研究人体生物利用度提供依据和参考。方法 :采用毛细管气相色谱 -电子捕获法测定 7只狗单剂量口服尼莫地平分子微囊剂和尼莫通片后的血药浓度并计算药动学参数。结果 :7只狗单剂量交叉实验后 ,实验结果经配对t检验进行统计 ,结果表明两制剂间有显著差异 ,与尼莫通片相比 ,尼莫地平分子微囊剂达峰值时间、平均滞留时间显著延长 ,相对生物利用度为 16 5 .0 %。结论 :尼莫地平分子微囊剂的生物利用度高于尼莫通片。更多还原

【Abstract】 Objective:To study the pharmacokinetics of nimodipine molecular microcapsule in dogs and to provide the evidence and reference of bioavailability in the study of human beings. Methods:The single-dose nimodipine tablets and molecular microcapsules were administered by seven dogs and their blood concentration was determined by GC-ECD method and the parameters of pharmacokinetics were counted. Results: The statistical analysis of the paired t test for the pharmacokinetic parameters showed that there was significant difference between the two products after the cross-over experiment in the seven dogs. The peak time (T max ) and mean residence time (MRT) of nimodipine molecular microcapsules were significantly longer than those of nimodipine tablets. The relative bioavailability was 165.0%. Conclusion: The bioavailability of nimodipine molecular microcapsule is higher than that of nimodipine tablet.更多还原