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无精症患者的染色体异常分析

Analysis of Chromosomal Abnormality in Azoospermia

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【作者】 金之瑾;

【Author】 JIN Zhi jin(Medical School, Ningbo University, Ningbo Institute of Medical Sciences, Ningbo Medical Molecular Diagnostic Center, Ningbo 315020, China)

【机构】 宁波大学医学院; 宁波市医学科学研究所; 宁波市医学分子诊断中心 浙江宁波315020;

【摘要】 目的 :分析男性无精症患者的染色体异常情况 .方法 :对 15 2例无精症患者进行常规外周血淋巴细胞培养、染色体制备及分析 .结果 :15 2例无精症患者中 ,5 5例的染色体结构或数目发生异常 ,占36 .18% ,其中以性染色体异常为主 .结论 :染色体异常是导致无精症的重要原因之一 ,遗传学病因研究对无精症患者的诊断和治疗具有重要意义

【Abstract】 Objective:To analyze chromosomal abnormality in azoospermia. Methods:Lymphocytes were cultured from peripheral blood of 152 cases with azoospermia, and then the chromosomes were prepared and analyzed. Results:Among the 152 cases with azoospermia, abnormalities in chromosomal structure and number, which were particularly in sex chromosomes, were found in 55(36.18%) cases. Conclusion:Chromosomal abnormality is an important factor that could lead to azoospermia. The study on genetics is important for diagnosis and treatment of azoospermia.

【关键词】 无精症; 染色体异常; 遗传学;
【Key words】 azoospermia; chromosomal abnormality; genetics;
  • 【文献出处】 宁波大学学报(理工版) ,Journal of Ningbo University(Natural Science & Engineering Edition) , 编辑部邮箱 ,2002年04期
  • 【分类号】R698
  • 【下载频次】50
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