【摘要】 目的　针对血清胆红素的强抗氧化性质 ,研究其与动脉粥样硬化 (AS)的关系。方法　采用重氮盐终点法测定血清胆红素 ,酶法测定总胆固醇 (TC)、甘油三酯 (TG)及高密度脂蛋白胆固醇 (HDLc) ,低密度脂蛋白胆固醇 (LDLc)则通过估计法 (公式为LDL =总胆固醇 甘油三酯 /5 +高密度脂蛋白胆固醇 )计算获得。结果　冠心病患者的总胆红素、直接胆红素及间接胆红素均低于对照组 (P <0 0 5 ) ,脑梗塞患者的总胆红素、间接胆红素低于对照组 (P <0 0 5 ) ,其他疾病组这三项指标与对照组比较无显著性差异 (P >0 0 5 )。结论　血清胆红素浓度低下引起体内抗氧化活性不同程度减弱 ,可能会促使脂质尤其是低密度脂蛋白 (LDL)氧化修饰增多 ,导致动脉粥样硬化的发生和发展。更多还原

【Abstract】 Objective To study the association of serum concentration of and its strong antioxidation with atherosclerosis.Methods Serum bilirubin was determined with Malloy Evelyn.Total cholesterol(TC),triglycerides(TG) and high density lipoproteins(HDLc)were determined with enzymology,low density lipoprotein(LDLc) was calculated with the formula that LDL=TC (TG/5+HDLc).Results The concentration of total bilirubin and indirect bilirubin in coronary heart disease were lower than those in the controls( P <0.05).The concentration of bilirubin in other diseases were the same as in the controls ( P >0 05).Conclusion Lower serum bilirubin concentration possibly reduces the antioxidant activities.It is possible to espedite lipid and low density lipoprotein peroxidation,lower serum bilirubin is associated with increased risk for atherosclerosis.更多还原