【摘要】 目的　评价ApoEε4与阿尔茨海默病及血管性痴呆的关系。 方法　对 15 6 0例老年患者 (平均年龄 77± 8岁 )进行ApoE等位基因测定 ;通过DSM Ⅳ标准将上述患者分为三组 ,进行统计分析。结果　在AD组中携带E4等位基因的患者为 30 9例 ,占此组的 5 0 % ,与非痴呆组比较差异有显著意义 (5 0 %vs32 % ,P<0 0 1)。ApoEε4 (P <0 0 0 0 1)、年龄 (P <0 0 0 0 1)、女性 (P <0 0 5 )是阿尔茨海默病发病的独立危险因素。ApoEε4 (P =0 6 9)不是血管性痴呆的独立危险因素。结论　ApoEε4与阿尔茨海默病有显著相关 ,是其发病的一个重要危险因素 ,但与血管性痴呆的关系仍不明确更多还原

【Abstract】 Objective To evaluate the relation of Apolipoprotein E gene polymorphisms with Alzheimer’s disease and Vascular dementia.Methods 1560 patients were divided into 3 groups according to the diognostic cirteria:no dementia(ND),Alzheimer’s disease(AD),Vascular dementia(VD),Apolipoprotein E allele was determined at the same time.Results There were significant increase of ApoEε4 in AD group compared with ND group(50% vs 32%,P<0.01).Under a logistic analysis:age,ApoEε4 and sex were independent risk factors of Alzheimer’s disease(P<0.0001,P<0.0001,P<0.05,respectively),age,cardio vascular disease were independent risk factors of Vascular dementia(P<0.001,P<0.01,respectively).ApoEε4 wasn’t a independent risk factor for VD.Conclusion ApoEε4 is an independent risk factor of Alzheimer’s disease.更多还原