【摘要】 目的 :观察海人藻酸 (KA)对大鼠脑乙酰胆碱能神经元毁损后 ACh E纤维的数目和形态的改变 ,以探讨何首乌 (PMT)对胆碱能纤维的保护作用及机制。方法 :采用兴奋性神经毒素海人藻酸 (KA)损伤基底前脑 (BF) Meynert核团 ,内侧隔核 (MS)及斜角带核 (DB) ,建立毁损模型 ,用何首乌喂饲毁损实验组 ,使用组织化学方法显示乙酰胆碱能纤维的改变及可能的用药后保护和活化作用。结果 :何首乌喂饲组 (A组 )比非何首乌喂饲组 (B组 ) ,其投射到海马及大脑皮质的 ACh E纤维数目多 ,纤维形态无破坏 ,差异有显著性 (P<0 .0 1)。结论 :何首乌对大鼠脑胆碱能神经投射纤维有保护作用更多还原

【Abstract】 Objective: To observe the number and morphology changes of rats’ cholinergic neurofibers under the destruction of Kainic acid and to investigate the protection and the mechnism of PMT to the AChE neurofibers. Methods: To inject excitative neurotoxin Kainic acid to the BF Meynert neucleus, MS neucleus and the Broca neucleus (DB) in order to estabolish the destruction model, then feeding the destructive experimental group, use the histochemistry method to display the changes of AChE fibers, also the protection and activation of PMT. Result: The number of projecting AChE fibers to the cortex and the hippocampus of group A is larger than that of group B, and group A shows no morphological destruction ( P <0.01). Conclusion: PMT hos protective effect to the rats projecting AchE Bibers.更多还原