【摘要】 目的 :初步探讨急性脑梗死患者血浆及脑脊液凝血纤溶变化机制 ,为临床提供诊治依据。方法 :急性脑梗死患者 35例 (采集血浆 ) ,其中 31例同时采集脑脊液 ,测定脑脊液及血浆部分凝血纤溶指标 ,并与正常对照组进行比较。结果 :急性脑梗死组脑脊液及血浆组织型纤溶酶原激活物 (t- PA)、 D-二聚体 (D- D)含量明显高于对照组 (P<0 .0 1) ;而纤溶酶原 (PL G)活性明显下降 (P<0 .0 1)。结论 :脑梗死急性期存在明显的高凝状态和继发性纤溶活性增高更多还原

【Abstract】 Objective:To measure the concentration of D dimer, t PA and PLG activity in plasma and cerebrospinal fluid in patients with acute cerebral infarction and to investigate their clinical significance. Methods: The concentration of D dimer and t PA in plasma and cerebrospinal fluid in patients was examined by enzyme linked immuno sorbent assay (ELISA) and the measurement for PLG biological activity was performed by the chromophore method. All these results were compared with control subjects. Results: The concentrations of D dimer and t PA in patients with acute cerebral infarction were much higher than normal subjects (P<0.01) while the PLG activity was significantly lower (P<0.01). Conclusion: Hypercoagulability and secondary hyperfibrinolysis exist in patients with acute cerebral infarction. And these hematological markers have clinical significance.\;更多还原