【摘要】 目的探讨钙调节激素在老年男性骨质疏松症发病机制中的作用,并了解患者骨密度和骨代谢生化指标变化的特点。方法测定93例体检老年男性的骨密度(BMD)、骨矿含量(BMC)、血清钙(Ca)、磷(P)、碱性磷酸酶(AKP)、骨钙素(BGP)、酸性磷酸酶(ACP)、甲状旁腺激素(PTH)、降钙素(CT)、25羟维生素D犤25(OH)-VitD犦及尿吡啶酚/肌酐(Pyd/Cr)比值,分为骨质疏松组与非骨质疏松组,并与42例中青年男性对照。结果老年男性组与中青年男性组比较、骨质疏松组与非骨质疏松组比较,BMD、CT、25(OH)-VitD降低(P<0.01),PTH增高(P<0.01),BGP、ACP、Pyd/Cr增高(P<0.05),Ca、P、AKP无明显差异。结论BMD和BMC是诊断男性骨质疏松症的主要依据,增龄、钙调节激素异常是老年男性骨质疏松症的重要原因,VitD缺乏是骨质疏松症发生的重要基础。更多还原

【Abstract】 Objective To investigate the role of calcium modulator hormone in the pathogenesis of osteoporosis in aged males, and to understand the characteristics of patient’s bone mass density(BMI) and biochemical indices of bone metabolism. Methods 93 aged males were divided into osteoporotic and non-osteoporotic groups. Determinations of BMD. and calcium(Ca),phosphorus(P), alkaline phosphate(AKP),osteocalein(BGP),acid phosphatase(ACP),parathyroid hormone(PTH),calcitonin(CT), 25-hydroxyl vitamin D[25(OH)-VitD] of serum, together with urine pyridinol/creatinine(Pyd/Cr) ratio. All these indices were compared with those obtained in 42 mid-aged and young males conttrol group. Results Aged male group compared to mid-aged and young male group.osteoporotic group compared to non-osteoporotic group. BMD,CT,25(OH)-VitD were reduced (P< 0.01);PTH increased (P< 0.01); BGP,ACP & Pyd/Cr,increased(P< 0.05). In regard to Ca,P,&AKP, there was no significant difference. Conclusions BMD and BMC(bone mineral content) are chief bases for diagnosis of osteoporosis in males. Aging, abnormality of calcium modulator hormone are important causes of osteoporosis in elderly males. Vitamin D dificiency is the important foundation for the occurrence of osteoporosis.更多还原