【摘要】 促性腺素释放激素 (GnRH)通过受体机制对垂体促性腺细胞分泌促卵泡素 /促黄体素(FSH/LH)进行调控。在整个细胞信号转导过程中 ,它与G蛋白结合受体家族Gq/ 11结合 ,导致一系列不同信号在细胞内传导 ,其中细胞内外Ca2 + 的释放、PKC的激活、JNK激活以及小分子G蛋白(Ras)的激活起到了关键性的作用。最终引起细胞内GnRH受体合成、LH/FSH合成和分泌、细胞生长、分化和增殖等生物学效应。更多还原

【Abstract】 The pituitary cells secreting FSH/LH is through a receptor action mechanism which is modulated by the GnRH. The signals are transducted throughout the procession by Gq/11, which is one of the proteins of G protein coupling receptor family. Among the process, there are several key factors needed to be activated, such as the releasing Ca ++ from both intercellular and extracellular, the activation of JNK and Ras. As a result, many biological effects are activated by GnRH, like synthesizing the receptor of GnRH, synthesizing and secreting FSH/LH, cell deferentiation and reproduction.更多还原