【摘要】 目的　评价金新动脉支架置入小型猪正常冠状动脉内的可行性 ,观察支架置入后各时相支架段血管开通情况及血管内膜反应。方法　将 39枚国产冠状动脉内支架置入 2 0头小型猪冠状动脉内 ,每头小型猪的左前降支及左回旋支各被置入支架 1枚 ,观察置入 2 4h、1周、2周、4周、12周及 6个月血液动力学、肝功能、肾功能变化及冠状动脉造影随访结果 ,并对支架置入段血管进行光镜及电镜检查。结果　①该种冠状动脉内支架置入成功率为 97 5 % ,支架置入对血液动力学、肝功能、肾功能无影响。②冠状动脉造影随访示所有支架置入即刻和动物处死前支架段血管开通率10 0 %。支架X光下清晰可见 ,未经特殊抗血栓治疗 ,支架段血管内无血栓形成。未见与置入支架有关的心脏事件发生。③组织病理学形态分析显示新生内膜由不同排列的纤维组织和平滑肌细胞 (SMCs)组成 ,置入支架 1周开始有内膜覆盖支架丝 ,2周时可检测到光滑的新生内膜 ,置入支架后 1周、2周、4周、12周、2 4周支架小梁处新生内膜厚度分别为(5 6 17± 31 15 ) μm、(10 9 72± 4 1 6 1) μm、(348 2 5±5 6 78) μm、(2 5 6 2 5± 5 5 97) μm、(14 8 6 1± 39 82 ) μm。支架小梁间新生内膜厚度分别为 (37 2 1± 2 7 5 0 ) μm、(6 4 5 6±36 5 7) μm、(1更多还原

【Abstract】 Objectives To assess the feasibility and the effects of a new kind of coronary stent (Jin xin coronary stent)after being implanted into normal coronary arteries of pigs. Methods In twenty mini pigs ,thirty nine stents were placed in LAD and LCX respectively.Hypatic function,nephric function and hemodynamics were observed and repeat angiography were performed,followed by pressure fixation of the coronary arteries for light and electron microscopic examination during the first day to 6 months after implantation.Results ① The successful rate of implantation of stent was 97.5%.There is no significant change in hypatic function,nephric function and hemodynamics after stenting. ②Repeated angiography showed that all stented coronary segments were open.With no additional antithrombotic treatment,there was no thrombus formed in stented coronary segments.No heart event which was correlative to stenting was found. ③Histopathology morphological analysis revealed the neointima was the thickest at 4 weeks after implantation and consisted mainly of an abundaut smooth cells.After 1 week,2 weeks,4 weeks,12 weeks,24 weeks,the thickness of neointima were (56 17±31 15) μm?(109 72±41 61) μm?( 348 25± 56 78) μm?(256 25±55 97) μm?(148 61±39 82) μm,repectively;and (37 21±27 50) μm?(64 56±36 57) μm?(112 56± 47 16) μm ?( 100 17± 37 15) μm?(32 25± 12 50) μm between wires,respectively.Conclusions Result from this study shows that this kind of stent can be safely placed in normal coronary arteries of minipigs.This stent could reduce the rate of the re stenosis and occlusion of PTCA . This stent can be used in clinical trials.更多还原