【摘要】 通过 2 -芳胺基 - 1,3,4 -噻二唑 - 5 -硫醇 1a,1b和头孢菌素母体 7- ACA的亲核取代反应 ,先制得头孢菌素新母体 1a,1b,用 1-芳基 - 5 -甲基 - 1,2 ,3-三唑 - 4 -甲酰氯 3a,3b与 2 a,2 b缩合 ,制得头孢菌素新衍生物 4 a,4 b.初步体外抗菌试验结果表明 ,所合成的头孢菌素衍生物 4 a,4 b对革兰氏阳性菌显示出中等程度的抑制活性 .更多还原

【Abstract】 New cephalosporin derivatives 4a,4b were prepared b y condensation of 2a,2b with-1-aryl-5-methyl - 1,2,3-triazol-4-formyl chloride 3a,3b. The new mother nu cleus 2a,2b were synthesized by reaction of 2-ar ylamino-1,3,4-thiadiazol-5-thiols 1a,1b with 7 ACA. The preliminary results of ant ibacterial activities revealed t hat 4a,4b showed moderate antibacterial activitie s against Gram positive bacteria.更多还原