【摘要】 目的 :探讨年轻人急性心肌梗死 (AMI)的发病机制。方法 :以 4 0岁以下男性患者为研究对象 ,分别检测血清性激素水平、血脂谱、T淋巴细胞亚群、丙二醛 (MDA)和超氧化物歧化酶 (SOD)等指标。结果 :①与正常对照组相比 ,年轻人AMI患者的 17β -雌二醇 (17β -E2 )血清水平明显增高 (P <0 .0 5 ) ,而总睾酮 (TT)、游离睾酮 (FT)显著下降及E2 /T比值明显增高 (P <0 .0 1) ;②甘油三脂 (TG)、低密度脂蛋白胆固醇 (LDL -C)较对照组显著增高 (P <0 .0 1) ,而高密度脂蛋白胆固醇 (HDL -C)和总胆固醇 (TC)无明显变化 ;③CD3+ 、CD4 + 、和CD8+ 与对照组相比 ,无显著差异 ;④MDA、SOD与对照组相比均具有显著差异(P <0 .0 1)。结论 :年轻人AMI存在血脂谱异常 ,末发现有免疫功能改变 ,E2 /T比值升高可能是其发病机理之一 ,自由基介导的脂质过氧化参与了年轻人AMI的发生。更多还原

【Abstract】 Objective: To investigate the mechanism of acute myocardial infarction (AMI) in young men (<40 years old). Methods: In our study, the serum levels of sex hormones, blood lipid profile, T lymphocyte subgroups, malondialdehyde(MDA)and superoxide dismutase(SOD)were measured in 32 young patients with AMI. Results: (1)Compared with the control group, the serum level of 17β- estradiol (17β-E 2 ) obviously increased ( P <0.05), but that of total testosterone (TT) and free testosterone (FT) significantly decreased and the ratio of E 2 /T obviously increased. (2)Serum concentrations of triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C) significantly increased( P <0.01), but the levels of high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC) remained unchanged. (3)There was no difference in all parameters of T cell subsets between the young AMI group and control. (4)The serum level of MDA was significantly increased( P <0.01), but the serum activity of SOD was reverse( P <0.01). Conclusion: These results suggest that blood lipid profile significantly changed but the immunological function was unchanged in young AMI men. The ratio’s rise of E 2 /T may be one of the mechanisms and the free radical-mediated lipid peroxidation may participate in the process of AMI in young men.更多还原