【摘要】 目的　 探讨芬妥拉明的镇痛作用。方法　 采用热板法测定神经病理性痛小鼠缩爪反应潜伏期 (HWL)和正常小鼠扭体数作为痛阈指标 ,观察腹腔注射芬妥拉明 (IP)的镇痛作用。 结果　IP4mg/kg芬妥拉明 1～ 3d小鼠HWL明显增加和扭体数明显减少 (P <0 .0 0 1)。结论　 芬妥拉明对正常或神经病理性痛小鼠有镇痛作用更多还原

【Abstract】 Objective To investigate the analgesic effects of phentolamine.Methods The latency of hindsaw withdrawal (HWL) on a hot plate in mononeuropathy mice and the writhing frequency in intact mice were used as pain threshold indexes.The analgesic effects of intraperitoneal injection of phentolamine were observed.Results The HWL was prolonged significantly and the writhing frequency was reduced when IP 4mg/kg phentolamine was applied (P<0.001).Conclusion The results suggest that phentolamine can be used to enhance the analgesic effect in mononeuropathy or normal mice.更多还原