【摘要】 为研究广州地区1996～1999年间淋球菌对抗生素敏感性的变迁,采用琼脂稀释法测定4种抗生素对622株淋球菌的最小抑菌浓度(MIC)。4年来大观霉素和头孢曲松MIC50和MIC90无明显变化;青霉素MIC轻度升高,耐药率由57.2%升至83.8%;环丙沙星变化最大,1999年MIC50、MIC90和MIC几何均数分别较1996年增高32、16和18.7倍,耐药率由17.6%骤增至78.4%。结果表明在广州大观霉素和头孢曲松为治疗淋病最佳药物。更多还原

【Abstract】 To survey the susceptibility of Neisseria gonorrhoeae in Guangzhou from 1999 to 1999 , the minimal inhibitory concentrations(MICs) of antibiotics were determined using the agar dilution method. Of 4 antibiotics, the susceptibility of ceftriaxone and spectinomycin remained stable, while MICs increased slightly for penicillin G and repidly for ciprofloxacin during the four years. MIC50, MIC90 and MICmean of ciprofloxacin in 1999 were 23,16 and 18.7 times higher than those in 1996 respectively,and the ciprofloxacin resistant rate raised quickly from 17.6% to 78.4% from 1996 to 1999. The findings showed that ceftriaxone and spectinomycin were the best antibiotics in treating gonorrhea in Guangzhou.更多还原