【摘要】 目的　研究 2型糖尿病患者血清可溶性细胞间粘附分子 1(sICAM 1)和可溶性E 选择素 (sE selectin)水平的变化。方法　应用酶联免疫吸附法测定 67例 2型糖尿病患者和 2 0例健康对照组的sICAM 1和sE selectin以及甘油三酯 (TG)水平。结果　 ( 1) 2型糖尿病组血清sICAM 1和sE selectin水平显著高于对照组 (P <0 .0 1) ,2型糖尿病有微血管病变组、有大血管病变组均高于无血管病变组 (P值均 <0 .0 5 ) ;( 2 ) 2型糖尿病患者血清sICAM 1和sE selectin之间呈正相关关系 (r =0 .9985 ,P <0 .0 1) ;( 3 )血清sICAM 1水平和TG之间呈正相关关系 (r =0 .415 ,P <0 .0 5 )。结论　血清sICAM 1和sE selectin参与了糖尿病大血管和微血管病变的发病过程 ,并可作为糖尿病病情变化的监测指标 ,2型糖尿病患者血清sICAM 1升高与高甘油三酯血症有关更多还原

【Abstract】 Obejective To investigate the change of serum levels of sICAM 1 and of sE selectin in type 2 diabetic patients.Methods Serum levels of sICAM 1 and sE selectin were measured with ELISA in 67 cases of type 2 dibetic patients and 20 cases of healthy subjects.Results ①The serum levels of sICAM 1 and sE selectin in type 2 diabetic patients were much higher than these in healthy controls respectively ( P < 0.01), serum levels of sICAM 1 and sE selectin in type 2 diabetic patients with microangiopathy and large vessel diseases were much higher than those in type 2 diabetic patients without vessel diseases( P < 0.05); ②Serum levels of sICAM 1 in type 2 diabetic patients had positive correlative with serum levels of sE selectin( r =0.9985, P <0.01);③Serum levels of sICAM 1 in type 2 diabetic patients had positive correlative with serum levels of hypertriglyceridemia( r =0.415. P <0.05).Conclusions Serum sICAM 1 and sE selectin might participate in the course of diabetic microangiopathy and large vessel disease.Serum levels of sICAM 1 and sE selectin are the useful markers in reflecting disease evolution in diabetes mellitus.The elevation of serum levels of sICAM 1 in type 2 diabetic patients is related to hypertriglyceridemia.更多还原