【摘要】 目的　研究牙周炎基础治疗前后IL 8水平的变化。方法　采用双抗夹心ABC ELISA法测定成人牙周炎患者 (AP)、健康对照以及牙周炎治疗前后患者的龈沟液中IL 8浓度和总量。结果　在疾病组和健康组之间以及牙周病治疗前后对照 ,IL 8浓度无统计学差异 (P >0 0 5 ) ,而IL 8总量、GCF量均存在着统计学差异 (P <0 0 5 ,P <0 0 0 1) ,并且发现治疗对IL 8水平有着明显影响。结论　IL 8总量在成人牙周炎病程中显示动态性改变 ,检验GCF中IL 8的水平对评价牙周炎的治疗是有价值的。更多还原

【Abstract】 Objective To study the changes of IL 8 levels in adult periodontitis before and after treatment.Methods The concentrations and total amounts of IL 8 cytokine in gingival crevicular fluids were determined by double antibody sandwich ABC ELISA method in adult periodontitis (before and after treatment) and the healthy control group.Results Singnificant differences of the total amounts of IL 8 and GCF volume were found between the healthy control and diseased group before and after treatment ( P <0 05, P <0 001 respectively), but no significant differences were found between the two groups in concentrations of IL 8 ( P >0 05). There were significant changes in the IL 8 levels before and after treatment.Conclusion These data indicated that the total amounts of IL 8 showed dynamic changes in adult periodontitis. The levels of IL 8 in GCF were valuable in judging the degree of adult periodontitis and helpful in guiding clinical treatment.更多还原