【摘要】 为探讨血管紧张素Ⅱ 1型受体拮抗剂Losartan对正常和肾血管性高血压大鼠冠状动脉循环和血流动力学的影响 ,采用狭窄左肾动脉的方法复制肾血管性高血压模型 ,连续测定麻醉状态下给药前后冠状动脉血流量、平均动脉压、心率和冠状动脉阻力。结果发现 ,Losartan明显降低高血压大鼠的平均动脉压和冠状动脉阻力 ,明显增加其冠状动脉血流量 ,而对其心率无明显影响 ;Losartan对正常大鼠各项指标影响不大。结果提示 ,在肾血管性高血压时血管紧张素Ⅱ是冠状动脉血流量减少的主要原因 ,而Losartan可逆转由血管紧张素Ⅱ引起的冠状动脉血流动力学的改变更多还原

【Abstract】 Aim To observe the effects of angiotensin Ⅱ 1 receptor antagonist Losartan on coronary and systemic hemodynamics in the normotensive and renovascular hypertension rats. Methods Coronary blood flow (CBF) intra-arterial blood pressure, heart rate, and coronary vascular resistance (CVR) were measured at rest, during isometric exercise before and 60 min after Losartan (25 mg/kg, ig). Results The drug induced a prompt, significant decrease in mean arterial pressure (MAP) and a sustained increase in CBF, but no effects to normotensive rats. Conclusions These observations suggest that angiotensin Ⅱ maintains the ability to alter the control mechanisms of CBF even under long-term conditions and that Losartan reverses the angiotensin Ⅱ-induced effects on coronary hemodynamic.更多还原