【摘要】 目的　探讨CoQ10对早期帕金森病大鼠模型的抗氧化治疗作用。方法　建立早期帕金森病的大鼠模型 ,A组术前一周开始预服CoQ10 ,持续五周 ,B组只建立模型不给CoQ10 ,C组为手术对照组 ,D组为空白对照组。手术四周后用APO诱导实验动物 ,观察各组行为学改变和检测大鼠中脑MDA含量及中脑黑质的形态学变化。结果　APO测试所有动物的行为变化 ,A组、B组分别与C组和D组比较均有显著差异 (P <0 0 1)。与B组比较 ,A组大鼠的中脑组织MDA含量明显减少 (P <0 0 5 ) ,中脑黑质的损伤亦较B组轻微。而C组与D组比较无统计学差异。结论　CoQ10能减轻 6 -OHDA对大鼠黑质DA神经元的脂质过氧化损伤。更多还原

【Abstract】 Objective In order to find a new treatment on PD in early stage,the effects of CoQ10 as an antioxidant on the model of PD in rats were studied. Methods The early-stage PD model was established by injecting 6-OHDA stereotactically into the striatum of rats. In Group A CoQ10 was administered for 5 weeks which began a week before injecting 6-OHDA.In Group B on CoQ10 was used only 6-OHDA injection. Group C with an operation injecting normal saline instead of injecting 6-OHDA and CoQ10.Group D are normal animals,no 6-OHDA injection,no CoQ10.Four weeks later we observed the changes of rats′ action after injecting APO.The morphological changes of substantia nigra were observed through the light microscope and the transmission electron microscope.Results When comparing group A and B to group C,statistical differences were observed as follows ( P <0 01) after injecting APO.Compared with group B,the content of MDA in group A was reduced significantly( P <0 05) and the injuries of substantial nigra were slighter.There′s no statistical significance between group C and group D.Conclusion CoQ10 could reduced the dopaminergic neurons′injuries of lipid peroxidation induced by 6-OHDA.The results indicate that CoQ10 could be a new treatment for PD.更多还原