【摘要】 观察消癃合剂对丙酸睾丸酮 (TP)诱发小鼠前列腺增生模型的作用。将小鼠随机分为对照组、模型组、消癃合剂大、中、小剂量组。除对照组外 ,其余小鼠每日按 5mg/kg皮下注射TP造模 ,在造模同时每日灌胃给药 1次。 3周后测定小鼠体重及前列腺重量、前列腺指数、前列腺组织HE及Feulgen染色 ,图像分析测定DNA含量。结果显示 :消癃合剂各剂量组前列腺重量、前列腺指数均显著低于模型组 (P <0 0 1) ;腺上皮增生受到抑制 ,腺腔分泌物亦较模型组减少 ;单个细胞核面积及积分灰度值均低于模型组 ,其中大剂量组具有显著意义 (P <0 0 1)。说明消癃合剂具有抑制TP诱发小鼠前列腺增生的作用更多还原

【Abstract】 The effects of Xiaolong Mixture (XM) on hyperplasia of prostate induced by testosterone propionate (TP) were studied in mice. The mice were randomly divided into the control group, model group, XM large dose group, XM medium dose group, and XM small dose group. A dose of TP, 5 mg/kg, was given by subcutaneous injection to all the mice except those in the control group, and at the same time, XM was given once daily to the mice by gastric perfusion. At the end of the third weeks, the measurement of the body weight, prostatic weight and prostatic index was carried out; HE and Feulgen’s staining of prostatic tissue were made; and the level of DNA was detected by image analysis. The results showed that as compared with those in the mice in the model group, the prostatic weight and prostatic index were significantly lower ( P <0 01), adenomatosis was inhibited, and the secretion in the lumen of gland was decreased in the mice in all the three XM treating groups; both the single karyon acreage and integral grey value were also lower in all the three XM treating groups, and especially, significantly lower in the XM large dose group ( P <0 01). The results suggest that XM can inhibit the occurrence of hyperplasia of prostate induced by TP in mice.更多还原