【摘要】 目的 :研究α转化生长因子 (TGFα)及其受体表皮生长因子受体 (EGFR)在乳腺癌中的表达特点 ,以及两者间的相互作用。并通过与已知预后因素的相关分析 ,研究它们各自在肿瘤发展中的作用。方法 :对 84例导管浸润型乳腺癌标本进行TGFα EGFR免疫组织化学双重标记 ,同时观察两者在非肿瘤及肿瘤组织的表达 ,并对结果进行单变量和多变量统计学分析。结果 :TGFα和EGFR在癌旁组织上皮细胞中均有表达 ,分别在 76 2 %和17 8%浸润癌细胞中表达 ,在 16 7%浸润癌细胞中同时表达。χ2 分析显示TGFα在浸润癌细胞中的表达只与ER阴性相关联 ,而EGFR的表达则与大体积肿瘤、炎性乳癌、腋窝淋巴结受累、不良肿瘤组织学分级 (SBRⅢ级 )以及雌孕激素受体阴性相关联。多变量统计分析显示 ,浸润癌细胞中TGFα的表达与炎性乳癌相关联 (P =0 0 48) ,而EGFR的表达则与雌激素受体阴性相关联 (P =0 0 0 2 )。结论 :TGFα和EGFR在乳腺癌组织中的表达与在非肿瘤组织中明显不同 ,并与乳腺癌不良愈后因素相关联 ,提示他们在乳腺癌的发展中起着重要作用。更多还原

【Abstract】 Objective:To analyze expression characteristic of transforming growth factor α(TGFα) and its receptor (EGF receptor, EGFR) and their interaction in breast cancer, and to evaluate their respective role in tumor progression and severity along with known prognostic parameters. Methodes:TGFα and EGFR were evaluated by dual immunostaining in a series of 84 invasive ductal breast carcinoma specimens, their expression was studied in non-malignant or malignant epithelium. Univariate and multivariate statistical analyses were performed. Results:Co-expression of TGFα and EGFR was found in all of the non-malignant breast epithelia adjacent to tumors. The expression of TGFα and EGFR were found in invasive epithelial tumor cells in 76.2% and 17.8% specimens, respectively?An autocrine loop with TGFα and EGFR expression in invasive carcinomas was detected in 16.7% of cases. By χ 2 analysis, expression of TGFα in invasive carcinomas was correlated only with absence of estrogen receptor,whereas that of EGFR was correlated with large tumor size, inflammatory carcinoma, node involvement, Scarff-Bloom-Richardson (SBR) grade III and absence of estrogen receptor. By multivariate analysis, TGFα expression in invasive tumor cells was related to inflammatory carcinoma (P=0.048), while EGFR expression was strongly correlated with absence of estrogen receptor (P=0.002). Conclusion:TGFα and EGFR expression are quite different in breast carcinoma than in non-malignant tissues, and are related to poor prognostic parameters, suggesting that their interaction could play an important role in the development of breast cancer.更多还原