【摘要】 目的 :观察心痛贴经皮给药治疗心肌缺血的疗效。方法 :iv 1.0 μ kg垂体后叶素致SD大鼠心肌缺血损伤 ,观察经皮给药后缺血心肌的心电图变化 ;结扎SD大鼠冠脉左前降支致心肌缺血 ,用 0 .5 %硝基四氮唑蓝 (N -BT)染色 ,把末染色的梗塞心肌剪下用滤纸吸干称重 ,计算梗塞心肌占心室重量的百分比 ;SC 8mg kgISO致SD大鼠心肌损伤 ,测血清及心肌CPK。结果 :心痛贴心前区贴敷 4 .4 9g kg、8.98g kg2 能明显抑制iv 1.0 μ kg垂体后叶素所致缺血心肌的心电图变化 ;降低SC 8mg kgISO所致损伤心肌血清CPK的水平 ;iv 3.4 5g kg心痛贴能明显缩小SD大鼠冠脉血管结扎所致心肌梗塞面积。结论 :心痛贴经皮给药可产生抗心肌缺血作用。更多还原

【Abstract】 Objective:To observe the effect of the heartache sticks on myocardial ischemia. Methods: Myocardial ischemia model of rats was induced by iv 1.0 U/kg pituitrin,SC 8 mg/kg ISO,and ligation of the anterior branch of the left coronary.Results:The heartache sticks 4.49 g/kg and 8.98 g/kg both obviously repressed the electrocardiogram variety induced by iv 1.0 U/kg pituitrin and lower the CPK level induced by SC 8 mg/kg ISO.Iv 3.45 g/kg of heartache sticks obviously contracted the cardiac infarction area induced by ligation of the anterior branch of the left coronary of SD rats.Conclusion: The heart sticks have function of anti-myocardial ischemia.更多还原