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金丝桃甙与维生素E对小鼠脑肝组织的保护作用

The Protective Effects of Hyperin and Vitamin E on the Tissues of Brain and Liver of Mice

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【作者】 韩喻美; 赵小曼; 晏金平;

【Author】 HAN Yu mei 1,ZHAO Xiao man 1, YAN Jin ping 2 (1.Department of Biochemistry, Jiangxi Medical College, Nanchang 330006,China; 2.Department of Examination,the Hospital for Women and Children Jiangxi, Nanchang 330006,China)

【机构】 江西医学院生物化学教研室; 江西省妇幼保健院检验科 江西南昌330006; 江西南昌330006; 江西南昌330006;

【摘要】 目的 :本文探讨金丝桃甙与维生素E对小鼠脑肝组织的保护作用。方法 :采用小鼠脑肝组织进行体外培养 ,分别加入金丝桃甙、维生素E测其一氧化氮 (NO)、丙二醛 (MDA)、超氧化物歧化酶 (SOD)含量。结果 :金丝桃甙与维生素E均能增加组织SOD活性及NO含量 ,降低MDA水平 ,可能是其发挥药理作用的机制之一。结论 :金丝桃甙与维生素E均对小鼠脑肝组织有保护作用

【Abstract】 Objective: To investigate the protective effects of hyperin and vitamin E on the tissues of brain and liver of mice. Methods: After the cells of brain and liver from mice were cultured in vitro with hyperin and vitamin E for a short time, their amounts of nitric oxide (NO), malondialdehyde (MDA), and superoxide dismutase (SOD) were determined. Results:Hyperin and vitamin E both increased SOD activity and NO amount of the tissues and decreased MDA level. Conclusion: Hyperin and vitamin E may play pharmacological roles in the protection of the tissues of brain and liver of mice.

【关键词】 金丝桃甙/药理学; 自由基; 脑肝组织; 动物,实验; 小鼠;
【Key words】 Hyperin; free radicals; brain and Liver; mice;
  • 【文献出处】 江西医学院学报 ,Acta Academiae Medicinae Jiangxi , 编辑部邮箱 ,2002年01期
  • 【分类号】R285.5
  • 【被引频次】25
  • 【下载频次】81
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