【摘要】 目的 :观察鼠大脑中动脉不同部位降钙素基因相关肽 (CGRP)能神经分布特征。方法 :应用免疫组织化学ABC法和神经交点计数法 ,观察 14只SD大鼠大脑的中动脉。结果 :大脑中动脉的近、中、末段均有黑色细线状的CGRP免疫反应阳性神经纤维 ,分布密度以近段明显为高 ,中段和末段依次降低 (P <0 .0 1) ;分布方式近、中和末段分别以环行型、网状型和纵行型为主。结论 :大脑中动脉不同部位CGRP能神经纤维有不同的分布方式和分布密度 ,表明CGRP能神经纤维在大脑中动脉不同部位可能发挥不同的调节作用更多还原

【Abstract】 Objective: To study the innervation of calcitonin gene related Peptidergic (CGRP ergic) nerve in the middle cerebral arteries of rats. Methods: immunohistochemical ABC technique and counting number of nerve intersections were used for 14 SD rats. Results: The immunopositive fibers with the black linear structure were observed in the different locations of the middle cerebral artery.The type of CGRP ergic nerve was mainly circular (57.14%) in the proximal of MCA, mostly meshwork (85.71%)in the middle, and mostly longitudinal at the end (85.71%), The density of fibers was the highest in the proximal of MCA and the lowest at the end. Conclusion: Statistical analysis indicates that there is a significant difference of density of fibers between each two locations of MCA and a different distribution characteristic as well. It suggests that the regulation of CGRP ergic nerve might differ in the different location of the middle cerebral artery.更多还原