【摘要】 目的 :观察具有益气养阴、活血通络作用的中药验方糖肾康对实验性糖尿病大鼠早期肾脏病变的作用及肾脏组织中转化生长因子 β1(TGF - β1)表达的影响。方法 :以胰岛 β细胞毒剂链脲佐菌素 (STZ)诱导产生大鼠糖尿病模型 ,将模型大鼠随机分成糖尿病组、糖肾康治疗组、卡托普利对照组 ,连续灌胃给药 4周 ,观察治疗前后血糖变化 ,尿微量白蛋白排泄 ,血、尿 β2 -MG水平 ,肾脏电镜超微结构及肾脏组织中TGF - β1的表达。结果 :糖肾康可降低糖尿病大鼠肾重 /体重比值 (P <0 .0 5 ) ;糖尿病模型大鼠尿微量白蛋白排泄明显减少 ,血 β2 -MG水平降低 ,尿β2 -MG含量减少 ,减轻 /延缓电镜下肾脏超微结构损害 ,抑制鼠肾组织中TGF - β1表达。结论 :糖肾康对实验性糖尿病肾病有防治作用 ,其机制可能与抑制组织中TGF - β1的表达有关。更多还原

【Abstract】 Objective: To observe the ameliorative effect of Tangshenkang (TSK) on renal lesions of early stage in experimental diabetic rats and to investigate the role of TSK on TGF-β 1 expression in renal tissue. Methods:The diabetic rats were randomly divided into three groups: group without treatment, group with captopril treatment, (the dosage of captopril was 50 mg·kg -1 ·d -1 ) and group with TSK treatment (the dosage of TSK was 27.50 mg·kg -1 ·d -1 ). The treatment last for 4 weeks. Results:TSK treatment attenuated the ratio of kidney and body weight.TSK treatment significantly attenuated the levels of Alb β 2-MG in urine and β 2-MG in blood in diabetic rats.TSK treatment attenuated the damages on kidney structure in diabetic rats.The expression of TGF-β 1 in TSK treating group was significantly lower than that of group without treatment. Conclusion: TSK exerted obviously ameliorative effect in renal function and structure in diabetic rats and the important mechanism may be TSKs decreasing the expressions of TGF-β 1 in diabetic rats.更多还原