【摘要】 该项目设计了适当的纳滤膜浓缩工艺,以提高6-APA生成率,6-APA成品的平均克分子收率达90.18%;设计了醋酸丁酯-乙醇结晶工艺;选择了合适的溶媒体系及控制pH值以确保6-APA的质量;对溶媒及副产品苯乙酸进行了回收利用,降低了成本,减少了环境污染。纳滤膜分离技术是使低浓度裂解高浓度结晶得以实现的关键技术。用于100t 6-APA生产线上取得良好效果。更多还原

【Abstract】 In order to increase the formation rate of 6-aminopenicillanic (6-APA), this subject designed a proper nanofiltration membrane concentration progress, the average gram molecule yield of 6-APA has reached 90.18% , and n-butyl acetate-alcohol crystallization process was developed. The quality of 6-APA was insured by selecting right dissolvant system and controlling pH value. The dissolvant and phenylacetic acid, the by-product, were recycled, so the cost was decreased and the pollution was reduced. Nanofiltration membrane separation technology is the key technology for realization of decomposition at low concentration and crystallization at high concentration. Good results have obtained by using this technology in production line of 6-APA with capacity of 100t/a.更多还原