【摘要】 以丙二酸二乙酯 (Ⅰ )为原料 ,经Grignard反应合成α 丁酮酸乙酯 (Ⅱ ) ,产率为 45 %。乙醛在室温下 ,用碳酸钾做催化剂 ,加入适量的α 丁酮酸乙酯 ,n(α 丁酮酸乙酯 )∶n(碳酸钾 ) =1 0∶1 1,反应 1 5h ,可得葫芦巴内酯 (Ⅲ ) ,产率为 6 7%。合成得到的Ⅲ经IR、GC -MS和1HNMR进行了鉴定。更多还原

【Abstract】 Ethyl α-oxobutanoate(Ⅱ)was prepared from diethyl oxalate(Ⅰ)via Grigrand reaction. The yield ofⅡwas 45%. At n(Ⅱ)∶n(K 2CO 3)=1.0∶1.1,fenugreck lactone(4,5-dimethyl-3-hydroxy-2(5H)-furanone,Ⅲ)was synthesized fromⅡand acetaldehyde with potassium carbonate as catalyst reacting for 1.5 h at room temperature.The yield of Ⅲ was 67%.The title compound Ⅲ was identified by IR, GC/MS and 1HNMR.更多还原