【摘要】 以反式 4 戊基环己烷甲酸为原料 ,通过氢化铝锂还原、溴代、格氏反应、醇脱水、催化氢化、脱甲基、高压催化氢化和重铬酸钠氧化等 8步反应合成了 4 [2′ (反式 4″ 戊基环己基 )乙基 ]环己酮 ,熔点 40 9℃ ,气相色谱测定其质量分数为 99 1%。通过红外光谱、核磁共振氢谱和质谱的分析 ,确定了目标化合物的结构。此种化合物可以作为制备乙烷类多环体系液晶的重要中间体更多还原

【Abstract】 The compound 4-[2′-(trans-4″-pentylcyclohexyl)ethyl]- cyclohexanone was synthesized from trans-4-pentylcyclohexanecarboxylic acid via eight step reactions,namely reduction with lithium aluminium hydride,substitution of hydroxyl by bromine,Grignard reaction,dehydration reaction,catalytic hydrogenation,demethylation,catalytic high-pressure hydrogenation and oxidation with sodium dichromate.The mass fraction of the product by GC was 99.1% and the melting point was 40.9 ℃.Structure of the compound was determined by IR, 1H-NMR and IE. The synthesized substance can be used as an important intermediate for multi-ring system liquid crystal compounds containing ethylene linkage.更多还原