【摘要】 目的 :探讨 2型糖尿病 (DM )患者血管内皮依赖性舒张功能的改变。方法 :用高分辨率超声检测 18例不伴微血管病变型DM患者、2 5例伴微血管病变型DM患者和 2 3例对照者的肱动脉流量介导的舒张 (FMD)和硝酸甘油介导的舒张 (NTG -MD)的功能。结果 :两组DM患者的FMD较对照组显著降低 [(8 0 3± 2 84) %和 (4 72± 2 79) %vs(10 .15± 3 86) % ,P分别为 <0 0 5及 0 0 1] ,其中伴微血管病变型DM组降低更明显 (P <0 0 1) ;不伴微血管病变型DM的NTG -MD与对照组比较无显著性差异 (P >0 0 5 ) ,但伴微血管病变型DM组的NTG -MD呈显著降低 [(10 72± 3 14 ) %vs(13 41± 3 97) %和 (13 0 3± 3 78) % ,P均 <0 0 5 ] ;FMD与空腹和餐后血糖水平及病程均呈负相关 (r =-0 .73、-0 .81、-0 .65 ,P均 <0 0 1)。结论 :2型DM患者存在显著的血管内皮功能障碍 ;肱动脉FDM的检测对DM患者的病情分析有重要的临床价值更多还原

【Abstract】 Objective:To explore the changes of endothelium-dependent vasodilatation in type 2 diabetes mellitus(DM).Method:18 cases of DM patients without microangiopathy and 25 cases of DM patients with microangiopathy and 23 cases of control subjects were observed in the forms of brachial artery flow-mediated dilation(FMD)and Nitroglycerin-mediated dilation (NTG-MD)by the high-resolution ultrasonography.Results:①FMD in two DM groups were respectively(8.03±2.84)% and (4.72±2.79)%,being significantly lower than that (10.15±3.86)% in the control group with P<0 05 and 0.01.Meanwhile the reductions of FMD in DM group with microangiopathy was more severe than in those without microangiopathy (P<0 01).②NTG-MD was observed less difference between DM group without microangiopathy and control group (P>0 05),but NTG-MD was decreased in DM group with microangiopathy compared with the other two groups[(10 72±3 14)%vs(13 41±3 97)% and (13 03±3 78)%,[WTBX]P<0 05].③FMD was negative correlated with blood glucose level and diabetes duration..③FMD was negative correlated with blood glucose level and diabetes duration.Conclusion:There was obvious dysfunction of vascular endothelium in type 2 DM.The detection of brachial artery FMD play an important role in evaluating the severity of type 2 DM.更多还原