【摘要】 目的　分析探讨血清细胞角蛋白 19片段 (CYFRA2 1 1)、恶性肿瘤特异性生长因子 (TSGF)、糖链抗原(CA5 0 )、癌胚抗原 (CEA)联合检测在消化道癌诊断中的价值。方法　连续收集各类消化道癌患者共 12 4例 ,同时设立非恶性肿瘤组和健康体检组作为对照 ;采用放射免疫或生物化学等方法检测血清CYFRA2 1- 1、TS GF、CA5 0、CEA的含量 ,然后进行比较分析。结果　消化道癌患者的血清CYFRA2 1- 1、TSGF、CA5 0、CEA含量分别为 (8.74± 17.15 )ng/ml、(81.76± 16 .0 1)U/ml、(18.80± 6 2 .0 2 )U/ml、(16 .89± 5 1.5 3)ng/ml,明显高于非恶性肿瘤组和 /或健康体检组 ,差异有显著性 (P <0 .0 5 )。CYFRA2 1- 1、TSGF、CA5 0、CEA测定对消化道癌的敏感度分别为 4 1.1%、75 .0 %、11.3%、12 .9% ,测定对恶性肿瘤的特异度分别为 91.7%、83.3%、98.6 %、93.1%。食管癌、胃癌、大肠癌、肝癌等的TSGF、CYFRA2 1- 1含量均明显高于对照组 ,差异有显著性 (P <0 .0 5 ) ,并且有较高的检测阳性率。结论　CYFRA2 1- 1和TSGF测定在消化道癌的临床诊断和普查中都有较重要的应用价值 ;联合检测血清CYFRA2 1- 1、TSGF、CA5 0、CEA含量能提高诊断的阳性率更多还原

【Abstract】 Objective To explore the significance of combined determination of serum cytokeratin 19 fragments (CYFRA21\|1)?tumor specific growth factor (TSGF)?carbohydrate antigen (CA50) and carcinoembryonic antigen (CEA) levels for diagnosis of digestive tract cancer.Methods The levels of serum CYFRA21\|1?TSGF?CA50?CEA were determined by immunoradiometric assay or biochemical determination in 124 patients with digestive tract cancer, compared with the levels of the controls in which there are 40 patients without malignant tumor and 32 persons for health examination, and then the results were analyzed.Results The levels of serum CYFRA21\|1?TSGF?CA50?CEA were 8.74±17.15(ng/ml)?81.76±16.01(U/ml)?18.80±62.02(U/ml)?16.89±51.53(ng/ml) respectively in the group of malignant tumor, and were significantly higher than those in the controls(\$P\$<0.05). The sensitivity of determination of CYFRA21\|1?TSGF?CA50?CEA were 41.1%? 75.0%? 11.3%?12.9% and the specificity were 91.7%? 83.3%? 98.6%?93.1% respectively for diagnosing malignant tumor. The levels of serum TSGF and CYFRA21\|1 in the patients with esophageal cancer, gastric carcinoma, colorectal cancer or hepatic carcinoma, were significantly higher than those in the control (\$P\$<0.05).Conclusion The determination of CYFRA21\|1 and TSGF is of value in clinical diagnosis for digestive tract cancer, and also in tumor mass screening; furthermore, combined determination of CYFRA21\|1?TSGF?CA50?CEA can increase the positive rate of diagnosis for malignant tumor.更多还原