【摘要】 目的观察模拟失重条件对人体左心舒张功能的影响 ,探讨其在航天后心血管功能失调中的作用。方法采用超声多谱勒技术观察了 6名健康青年男性在 2 1d - 6°头低卧位模拟失重前、实验第 1 0、2 1天及实验后左心舒张功能变化 ,同时检查其卧床前后的立位耐力改变。结果被试者左心舒张功能指标 :经二尖瓣血流E峰最大流速 (PEV)、A峰最大流速 (PAV)、E峰血流速度积分 (VTIE)指标在实验第1 0、2 1天均较实验前有明显的降低 (P <0 .0 5 ) ;而A峰血流速度积分 (VTIA) ,峰值血流速度比值 (A/E)及血流速度积分比值 (VTIA/E)的下降则未达到显著水平 (P >0 .0 5 )。 6名被试者均未能通过立位耐力检查。结论模拟失重可引起人体左心舒张功能的显著下降更多还原

【Abstract】 Objective To investigate the effects of head down bed rest(HDBR),the simulated weightlessness, on the diastolic function of human left ventricle, and to discuss its role in cardiovascular deconditioning after space flight. Method Six healthy young volunteers were subjected to -6° HDBR for 21 d. Ultrasound Doppler technique was used to examine the changes of the diastolic function before, on the 10th, and 21st day during and 2nd day after HDBR. The orthostatic tolerance was also tested before and after HDBR. Result Peak E wave velocity(PEV), peak A wave velocity(PAV), and velocity total integration of E wave(VTI E), were significantly decreased (P<0.05)on the 10th and 21st day during and the 2nd day after HDBR, and velocity, total integration of A wave(VTI A), ratio of E/A, and ratio of VTI E/A were also decreased, but did not reach the significant level(P>0.05). None of the six subjects passed the orthostatic tolerance test after HDBR. Conclusion Simulated weightlessness can induce marked decline in diastolic function of human left ventricle.更多还原