【摘要】 目的探讨自体微小颗粒骨复合红骨髓治疗骨缺损的效果,为其应用于临床提供实验依据。方法将21只新西兰白兔双侧尺骨中段制成骨缺损模型,分别植入自体微小颗粒骨和自体微小颗粒骨与红骨髓复合物,同时设立空白对照,分别于术后4W、7W进行大体形态、X线检查及组织学检查。术后9W进行生物力学测试,比较修复骨缺损的疗效。结果 术后7W自体微小颗粒骨复合红骨髓更有效地修复节段性骨缺损,空白组无骨愈合迹象;术后9W生物力学测试证明自体微小颗粒骨复合红骨髓骨的力学性能明显优于对照组。结论 自体微小颗粒骨复合红骨髓成骨速度快,成骨量多,骨的机械强度高,修复骨缺损的能力明显强于自体微小颗粒骨移植。更多还原

【Abstract】 Objective To investigate the efficacy of repairing bone defect with the compound of red bone mar-row(RBM) and autogenous micro grain bone.Methods The animal models of bilateral ulna bone defect were creacted by surgery in the 21 New Zealand white rabbits and were treated with the autogenous micro grain bone and the compound of RBM by autograft.No implant as control the effect was observed by gross,histopathologi-cal and X-ray examinations at 4,7 weeks after operation and was determined by biomechanics at 9 weeks. Results The group of RBM-autogenous micro grain bone-composite repaired bone defect more effectually at 4, 7 weeks,but not with the no implant group. The effect of biomechanics had statistically significant different between the group of autogenous micro grain bone and the group of RBM-autogenous micro grain bone-composite at 9 weeks. Conclusion The group of RBM-autogenous micro grain bone-composite possesses much faster os-teogenesis and has more quantity of substitution bone and can repair bony defect more efficiently than the group of autogenous micro grain bone.更多还原