【摘要】 目的　研制一种新型的胰岛素 (INS)纳米粒 (NP)制剂。方法　以聚乳酸 (PLA)为载体材料 ,采用溶剂 -非溶剂法制备了INS -PLA -NP ,观察形态并测定粒径。给正常大鼠皮下注射 2U·kg-1INS溶液和 2U·kg-1INS -PLA -NP并观察降血糖作用。结果　INS -PLA -NP平均粒径为 84 34± 14 76nm ,给药后 0 5h血糖即降至最低(43 82 %± 10 4 1% ) ,并具有良好的缓释作用 ,药理相对生物利用度达到 133 5 1%。结论　制备工艺可行且制得的INS -PLA -NP在形态、粒径、载药特性、释药过程等方面令人满意更多还原

【Abstract】 OBJECTIVE To develop a new insulin(INS)-loaded nanoparticle(NP).METHODS With the use of poly lactic acid(PLA),INS-PLA-NP was prepared by solvent-nonsolvent method.2 U·kg -1 INS solution and INS-PLA-NP were subcutaneously injected in normal rats and hypoglycemic effect was observed.RESULTS The mean diameter of INS-PLA-NP was 84.34±14.76 nm.After the administration of INS-PLA-NP,glucose levels dropped to 43.82%±10.41% in 0.5 h.The pharmacological bioavailability was 133.51%.CONCLUSION The preparation technique was practical.The basic pharmaceutical characteristics of INS-PLA-NP were satisfactory.更多还原