【摘要】 目的　探讨光和热同时对诺氟沙星注射液稳定性的影响。方法　采用在高温下进行光照试验的方法。结果　该药物在恒温避光加速试验或高温下光照试验中的降解均遵从零级动力学规律。结论　在高温和光照同时作用下的降解速率常数ktotal由两部分构成 :ktotal=kdark+klight,kdark和klight分别为避光时热反应的降解速率常数及光化反应的降解速率常数 ,且klight=Alight×exp(-Ea ,light/RT)·E。更多还原

【Abstract】 OBJECTIVE To study the effect of both light and heat on the stability of Norfloxacin injection. METHODS The accelerated tests upon exposure to light at high temperatures were employed. RESULTS The degradation of Norfloxacin injection in isothermal heating experiments or the exposure experiments to light at high temperatures obey zero order kinetics. CONCLUSION The total degradation rate constant k total caused by both light and heat can be divided into two patrs:k total=k dark+k light,where k dark and k aight are the degradation rate constant caused by heat and light,respectively.The k light can be expressed as k light=A light·exp(-E a,light/RT)·E, where E is the illuminance of light; E a,light and A light are experimental constants related to the light sources.更多还原