【摘要】 目的　研究巴巴多斯芦荟多糖 (AP)对内毒素化大鼠和正常高龄大鼠血清及肝组织高过氧化脂质 (LPO)水平的影响。方法　各试验组动物连续 30d灌胃 ,给予不同剂量AP ,于试验开始的第 2 0天起连续 10d腹腔注射K0 3肺炎杆菌内毒素 (LPS 5 0 μg·kg-1)诱发大鼠高过氧化脂质产生 ;对照组均采用生理盐水。测定各试验组动物血清及肝组织中LPO的体内代谢产物丙二醛 (MDA)水平 ,以血清及肝组织MDA水平为指标 ,评价口服AP预防脂质过氧化作用。结果　口服AP 10 μg·kg-1和 5 0 μg·kg-1均能显著降低内毒素化少龄大鼠和正常高龄大鼠血清及肝组织LPO的水平。结论　AP具有一定的抗脂质过氧化作用。更多还原

【Abstract】 OBJECTIVE To evaluate the effects of polysaccharide extract (AP) from Aloe Vera on LPO( high level lipid peroxide) of serum and hepatic tissue.METHODS Animals were orally administered with different doses of AP for 30 days continuously; animal model of LPO was established by the treatment of 50 mg·g -1 LPS ip for 10 days continuously from the 21th day of the test. In addition, the control group was treated with NS. LPOconcentration of serum and hepatic tissue were measured to evaluate the preventive effect of anti oxidation of AP.RESULTS The results showed that AP at the doses of 10 mg·kg -1 and 50 mg·kg -1 could decrease the LPO concentration of serum and hepatic tissue in young endotoxinic and normal old rats obviously.CONCLUSION AP has an obvious effect of anti oxidation.更多还原