【摘要】 采用PVP Pd IrO2 Nafion修饰电极对成纤维细胞中NO的释放情况进行了研究 .结果表明 ,在正常状态下 ,采用NO前体L 精氨酸和乙酰胆碱对成纤维细胞进行刺激后没有NO的释放 ;当用脂多糖进行诱导后 ,则释放出高浓度的NO ,加入L 精氨酸和乙酰胆碱都促进了NO的合成 ,而L NNA的加入则逆转了L 精氨酸和乙酰胆碱的作用 .更多还原

【Abstract】 PVP/Pd/IrO 2/Nafion microsensor was fabricated to measure nitric oxide production in fibrocytes directly. In the experiments, fibrocytes did not release nitric oxide after stimulated with L arginine and acetylcholine under normal condition. After induced with lipopolysaccharide, NO was produced in high concentration and NO levels were increased after stimulated with L arginine and acetylcholine. On the other hand, L N ω nitro arginine, an NO synthase inhibitor, decreased the action of L arginine and acetylcholine.更多还原